Depression, Helplessness, and Aging II

Death from helplessness has been widely observed in animals and people. In one study, wild rats forced to swim until exhaustion lasted for 60 hours before they drowned. Rats that were first held firmly in the investigator’ hand until they stopped struggling, and were then put in the water, swam frantically for about 30 minutes, […]

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The Decline of Your Brain’s Chemical Messengers III

Catecholamines are responsible for a number of different effects in normal humans. They are involved in control of locomotor (moving about) behavior, aggressive behavior, sexual behavior, food intake, and behavior dependent upon positive (reward) and negative (punishment) reinforcement. Acetylcholine controls muscle tone and motor activity and has a role in memory, learning, and long-term planning, […]

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Aging and the Immune System III

Selenium, a mineral, is an important trace element in immune system function. It has been found in experimental animals to act as an anti-carcinogen and anti-mutagen (can prevent DNA mutations—undesired alterations of your DNA master blueprint in the presence of some mutagenic agents). Selenium is an essential part of your enzyme called glutathione peroxidase, which […]

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Aging and the Immune System I

… just as the pigment of the hair is destroyed by phagocytes, so also the atrophy of other organs of the body, in old age, is very frequently due to the action of devouring cells which I have called macrophages. —Elie Metchnikoff, The Prolongation of Life (1908) Instead of preventing diseases only by protecting the […]

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Prolonging Life in the Laboratory; or, Why Animal Experiments Are Relevant to Humans

The most beautiful thing we can experience is the mysterious. It is the source of all true art and all science. He to whom this emotion is a stranger, who can no longer pause to wonder and stand rapt in awe, is as good as dead: his eyes are closed. —Albert Einstein Most biological experiments […]

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