Male Pattern Baldness and What You Can Do About It I

… Just as the pigment of the hair is destroyed by phagocytes, so also the atrophy of other organs of the body, in old age, is very frequently due to the action of devouring cells which I have called macrophages. —Elie Metchnikoff, The Prolongation of Life (1908) Male pattern baldness is an example of an […]

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Factors Which Correlate with Natural Longevity I

Some years before birth, advertise for a couple of parents belonging to long-lived families. —Oliver Wendell Holmes, Sr. There is great variation in the longevity we see among people. We are all aware that a small percentage of people live to be over 100 years old, living much longer than the vast majority of us. […]

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Factors Which Correlate with Natural Longevity III

interfere with PAH activation and/or binding to DNA, thereby reducing the amount of DNA damage done. Rate and accuracy of repair of ultraviolet (UV) light damage to DNA in seven mammalian species’ cultured fibroblasts correlates with maximum species life span. Repair of damage to DNA plays a vital role in retarding aging, although the importance […]

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Regeneration: Born-Again Limbs and Organs I

Jupiter had Prometheus chained to a rock on Mount Caucasus, where a vulture preyed on his liver, which was renewed as fast as devoured. —Greek mythology The blueprints for every part of our body are stored on our DNA. We each developed from a fertilized egg that slowly unfolded to the complex beings we now […]

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Our Subversive Free Radicals I

… Spontaneous mutations, cancer, and aging can be looked upon as a result of continuous “internal radiation” while these same processes produced by external radiation are largely the result of an increment in the amount of total “radiation” to which the organism is exposed. —Dr. Denham Harman, originator of the free radical theory of aging […]

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Turning Back Aging Clocks III

As mentioned earlier, Dr. W. Donner Denckla thinks he has discovered a death clock in the pituitary gland of the brain. If he removes this gland from mice and supplies them with the pituitary’s growth hormone and thyroid hormone (which would normally be produced and released in response to pituitary hormonal messages), the animals live […]

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Turning Back Aging Clocks I

Everyone is familiar with the so-called “annual” plants which live only a few months, from the time when they sprout, until, after the production of seed, death comes to them naturally. … Natural death can be postponed if the plant be prevented from seeding. —Elie Metchnikoff, The Prolongation of Life (1908) Do DNA genetic clocks […]

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Our Subversive Free Radicals II

Mutations to your DNA caused by free radicals are a major cause of cancer. Free radicals can make blood clot abnormally in our arteries by destroying our body’s ability to make PGI, (prostacyclin), a natural anti-clot hormone found in healthy arteries. Free radicals are also implicated in arthritis. Most of the brain damage caused by […]

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Cross-linked Molecules and Aging in Skin, Arteries, and Other Tissues IV

Skin is a visible organ which suffers cross-linking damage. However, unlike other tissues, skin is exposed to considerable ultraviolet light (UV) energy from sunlight. Ultraviolet light is a major cause of skin cross-linking. This type of damage can be prevented or retarded by staying out of sunlight or using sun-block preparations containing esters of PABA […]

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Cross-linked Molecules and Aging in Skin, Arteries, and Other Tissues I

Empiricism may serve to accumulate facts, but it will never build science. The experimenter who does not know what he is looking for will not understand what he finds. —Claude Bernard, 1813-1878 When your skin wrinkles, or arteries or bread hardens, or rubber becomes brittle, or old Jell-O® stiffens, we are seeing examples of the […]

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