Although the work was directed at amyloid formation, data was also cited that showed the pronounced beneficial effect on the mice’s mortality rate by adding Santoquin antioxidant to the diet. Without the antioxidant in the diet, 20% survived to 1814 months; on diets with 0.2% Santoquin, 20% survived for 23 months. This was not the […]
Read more Our Subversive Free Radicals VIII
- amino acid, amyloid formation, antioxidants, encephalomalacia, free radicals, lipids, Monsanto, nutrients, oxidation, oxygen, peroxides, Santoquin, unsaturated fats, unsaturated oils, vitamin E, vitamins
Santoquin antioxidant, more familar as a commonly-used feed ingredient by its generic nickname of ethoxyquin, is feed- grade: 6-ethoxy-1,2-dihydro-2,2,4-trimethylquinoline. The structural formula looks like this: H NW CH, CH, CH;CH,O a CH; One of the most familiar (and perhaps important) antioxidants that Mother Nature provides living bodies is Vitamin E. Its most potent isomer, -tocopherol […]
Read more Our Subversive Free Radicals VII
- aging, aging pigments, amyloid plaques, amyloidosis, antioxidants, Cross-linking, digestion, Dr. B. L. Strehler, Dr. Denham Harman, Dr. Johan Bjorksten, Dr. William A. Pryor, ethoxyquin, free radicals, metabolism, Monsanto, peroxides, Santoquin, senile plaques, vitamin E
Hydergine® (made by Sandoz), a prescription drug, can prevent a considerable amount of the damage caused by free radicals in the brain. It is a very powerful antioxidant. It is useful in older persons who have a degree of cerebral hypoxia (insufficient oxygen), in preventing birth defects resulting from inadequate oxygen to the fetal brain […]
Read more Our Subversive Free Radicals VI
- 2-MEA, age pigments, alertness, amino acid, antioxidants, B-cells, BHT, birth defects, brain, brain damage, cerebral palsy, cognitive functions, cysteine, ethoxyquin, extending life span, free radicals, hydergine, hypoxia, increased intelligence, Lipofuscin aging pigment, Monsanto, neurons, nootropic, peroxidized fats, prescription drugs, proteinaceous material, sandoz, Santoquin, selenium, skin, sodium hypophosphite, T-cells, vitamin A, vitamin E, zinc
BHT has extended the life spans of mice in experiments by Dr. Denham Harman. In some species which have a naturally short life span and tend to die of cancer, the BHT’s life extending effects probably stemmed from its suppression of cancer development. Harman has also demonstrated an increase in average life span with BHT […]
Read more Our Subversive Free Radicals V
- antioxidants, autoxidation, beta-blocker drug, BHA, BHT, brain, calories, cancer, cardiovacular disease, central nervous system, cerebral-spinal fluid, CNS, copper, CSF, cysteine, docosahexanoic acid, Dr. Denham Harman, free radical theory of aging, free radicals, free-radicals, high blood pressure, immune system, linolenic acid, lipids, low dose of aspirin, oxidation, polyunsaturated fats, propranolol, safflower oil, saturated fats, selenium, SOD, spinal cord, stomach cancer, vitamin A, vitamin B1, vitamin B5, vitamin B6, vitamin c, vitamin E, zinc
Mutations to your DNA caused by free radicals are a major cause of cancer. Free radicals can make blood clot abnormally in our arteries by destroying our body’s ability to make PGI, (prostacyclin), a natural anti-clot hormone found in healthy arteries. Free radicals are also implicated in arthritis. Most of the brain damage caused by […]
Read more Our Subversive Free Radicals II
- age pigment accumulation, amino acid, antioxidants, arthritis, bacteria, BHA, BHT, bioflavinoids, blood clot, blood clots, cancer, catecholic amino acid, ceroid, collagen, Cross-linking, cysteine, DNA, elastin, enzymes, free radicals, glutathione, grapes, hemorrhage, hydrogen peroxide, Hydroxyl radicals, L-Dopa, lipid membrane peroxidation, lipids, lipofuscin, lysosomal membranes, mutations, oxidative polymerization, oxygen, peroxidation, peroxidized lipids, PGI, phenolic amino acid, prostacyclin, proteins, radiation, rancid fats, RNA, selenium, sodium hydrogen urate, superoxide radicals, triamino acid, tyrosine, unsaturated fats, uric acid, viruses, vitamin A, vitamin B1, vitamin B5, vitamin B6, vitamin E, xanthine oxidase, zinc
Free radicals are intermediates in many normal and necessary metabolic reactions. Thus, all oxygen-using organisms have had to evolve defensive mechanisms against free radicals: The enzymes catalase and peroxidase break down hydrogen peroxide and other peroxides, superoxide dismutase (called SOD) controls the superoxide free radical, and glutathione peroxidase also controls peroxides. Antioxidants such as vitamins […]
Read more Our Subversive Free Radicals III
- acid hydrolases, air pollution, antioxidants, bacteria, bioavailability, brain, cancer, catalase, Cross-linking, enzymes, free radicals, genetic defects, glutathione peroxidase, heart, hyaluronate, hydrogen peroxide, liver, lysosomes, malonaldehyde, maximum lifespan potential, metabolic reactions, mlp, mutagen, oxidation, peroxidase, peroxidized fats, progeria, radiodurans, red blood cells, rheumatoid arthritis, selenium, SOD, superoxide dimutase, superoxide dismutase, superoxide radicals, vitamin E
where: R is an organic molecule ROOH is an organic peroxide R:R are two organic molecules which have been cross-linked to- gether Oz is oxygen Cu is copper, Fe is iron *is the unpaired electron H is a hydrogen atom HO* is a superoxide free radical RO,* and R* are organic free radicals Note that […]
Read more Our Subversive Free Radicals IV
- aging, amino acid, antioxidants, artery walls, atherosclerotic plaque cells, BHA, BHT, cancer, coronary thrombosis, cysteine, Dr. Wilfred E. Shute, ethoxyquin, free radicals, genetic mutations, glutathione, heart attack, L-Dopa, Lasker research award, peroxidized fats, PGI, phenolic amino acid, platelet, prostacyclin, prostacyclin synthetase, selenium, stroke, sulfur, thromboxane, tyrosine, vitamin A, vitamin c, vitamin E
As we mentioned earlier, some nutrients effective to a degree in slowing cross-linking include cysteine (a sulfur-containing amino acid, which helps maintain sulfur in proteins in the reduced state); vitamins A, B-1, B-5, B-6, C, E; the mineral selenium; and other antioxidants. Removal of calcium and heavy metals from collagen by chelating agents may be […]
Read more Cross-linked Molecules and Aging in Skin, Arteries, and Other Tissues V
- amino acid, bromelain, chelating agent, collagen, Cross-linking, cysteine, Dr. Johan Bjorksten, micro-protease, nutrients, papain, papaya, pineapple, proteolytic enzymes, sulfur, vitamin A, vitamin B1, vitamin B5, vitamin B6, vitamin c, vitamin E
As you grow older, your body becomes stiffer, less elastic, and less agile. This is due to cross-linking at a molecular level. You become stiffer for the same reason that old rubber becomes brittle and stiff—your large structural molecules such as collagen (an important protein in connective tissues) are welded together by cross-links. This process […]
Read more Cross-linked Molecules and Aging in Skin, Arteries, and Other Tissues II
- agile, bitamin B1, collagen, Cross-linking, flexibility, molecules, nutrients, PABA, vitamin A, vitamin B5, vitamin B6, vitamin c, vitamin E
Selenium, a mineral, is an important trace element in immune system function. It has been found in experimental animals to act as an anti-carcinogen and anti-mutagen (can prevent DNA mutations—undesired alterations of your DNA master blueprint in the presence of some mutagenic agents). Selenium is an essential part of your enzyme called glutathione peroxidase, which […]
Read more Aging and the Immune System III
- Allan L. Goldstein, anti-carcinogen, anti-mutagen, aorta, bacteria, bromelain, cholesterol, DNA, Dr. Takashi Makiodan, enzymes, fibroblasts, glutathione peroxidase, high-cholesterol diet, hydrogen peroxide, immune system, immune system suppressants, interferon, lymphocytes, oxidation, papain, peroxides, selenium, stem cells, T-cells, thymosin, thymus gland, trypsin, vitamin A, vitamin c, vitamin E, white blood cells