Cross-linked Molecules and Aging in Skin, Arteries, and Other Tissues III

Proteins are complex molecules, made up of amino acids, which perform a wide variety of functions in the human body, from chemical reaction-controlling enzymes, to structural molecules like collagen, to necessary components in human memory. In order to function properly, proteins must assume a correct three-dimensional configuration. In their proper shape, some proteins act as […]

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Cross-linked Molecules and Aging in Skin, Arteries, and Other Tissues II

As you grow older, your body becomes stiffer, less elastic, and less agile. This is due to cross-linking at a molecular level. You become stiffer for the same reason that old rubber becomes brittle and stiff—your large structural molecules such as collagen (an important protein in connective tissues) are welded together by cross-links. This process […]

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Cross-linked Molecules and Aging in Skin, Arteries, and Other Tissues I

Empiricism may serve to accumulate facts, but it will never build science. The experimenter who does not know what he is looking for will not understand what he finds. —Claude Bernard, 1813-1878 When your skin wrinkles, or arteries or bread hardens, or rubber becomes brittle, or old Jell-O® stiffens, we are seeing examples of the […]

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