Hydergine® (made by Sandoz), a prescription drug, can prevent a considerable amount of the damage caused by free radicals in the brain. It is a very powerful antioxidant. It is useful in older persons who have a degree of cerebral hypoxia (insufficient oxygen), in preventing birth defects resulting from inadequate oxygen to the fetal brain […]
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- 2-MEA, age pigments, alertness, amino acid, antioxidants, B-cells, BHT, birth defects, brain, brain damage, cerebral palsy, cognitive functions, cysteine, ethoxyquin, extending life span, free radicals, hydergine, hypoxia, increased intelligence, Lipofuscin aging pigment, Monsanto, neurons, nootropic, peroxidized fats, prescription drugs, proteinaceous material, sandoz, Santoquin, selenium, skin, sodium hypophosphite, T-cells, vitamin A, vitamin E, zinc
BHT has extended the life spans of mice in experiments by Dr. Denham Harman. In some species which have a naturally short life span and tend to die of cancer, the BHT’s life extending effects probably stemmed from its suppression of cancer development. Harman has also demonstrated an increase in average life span with BHT […]
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- antioxidants, autoxidation, beta-blocker drug, BHA, BHT, brain, calories, cancer, cardiovacular disease, central nervous system, cerebral-spinal fluid, CNS, copper, CSF, cysteine, docosahexanoic acid, Dr. Denham Harman, free radical theory of aging, free radicals, free-radicals, high blood pressure, immune system, linolenic acid, lipids, low dose of aspirin, oxidation, polyunsaturated fats, propranolol, safflower oil, saturated fats, selenium, SOD, spinal cord, stomach cancer, vitamin A, vitamin B1, vitamin B5, vitamin B6, vitamin c, vitamin E, zinc
Mutations to your DNA caused by free radicals are a major cause of cancer. Free radicals can make blood clot abnormally in our arteries by destroying our body’s ability to make PGI, (prostacyclin), a natural anti-clot hormone found in healthy arteries. Free radicals are also implicated in arthritis. Most of the brain damage caused by […]
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- age pigment accumulation, amino acid, antioxidants, arthritis, bacteria, BHA, BHT, bioflavinoids, blood clot, blood clots, cancer, catecholic amino acid, ceroid, collagen, Cross-linking, cysteine, DNA, elastin, enzymes, free radicals, glutathione, grapes, hemorrhage, hydrogen peroxide, Hydroxyl radicals, L-Dopa, lipid membrane peroxidation, lipids, lipofuscin, lysosomal membranes, mutations, oxidative polymerization, oxygen, peroxidation, peroxidized lipids, PGI, phenolic amino acid, prostacyclin, proteins, radiation, rancid fats, RNA, selenium, sodium hydrogen urate, superoxide radicals, triamino acid, tyrosine, unsaturated fats, uric acid, viruses, vitamin A, vitamin B1, vitamin B5, vitamin B6, vitamin E, xanthine oxidase, zinc
Free radicals are intermediates in many normal and necessary metabolic reactions. Thus, all oxygen-using organisms have had to evolve defensive mechanisms against free radicals: The enzymes catalase and peroxidase break down hydrogen peroxide and other peroxides, superoxide dismutase (called SOD) controls the superoxide free radical, and glutathione peroxidase also controls peroxides. Antioxidants such as vitamins […]
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- acid hydrolases, air pollution, antioxidants, bacteria, bioavailability, brain, cancer, catalase, Cross-linking, enzymes, free radicals, genetic defects, glutathione peroxidase, heart, hyaluronate, hydrogen peroxide, liver, lysosomes, malonaldehyde, maximum lifespan potential, metabolic reactions, mlp, mutagen, oxidation, peroxidase, peroxidized fats, progeria, radiodurans, red blood cells, rheumatoid arthritis, selenium, SOD, superoxide dimutase, superoxide dismutase, superoxide radicals, vitamin E
where: R is an organic molecule ROOH is an organic peroxide R:R are two organic molecules which have been cross-linked to- gether Oz is oxygen Cu is copper, Fe is iron *is the unpaired electron H is a hydrogen atom HO* is a superoxide free radical RO,* and R* are organic free radicals Note that […]
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- aging, amino acid, antioxidants, artery walls, atherosclerotic plaque cells, BHA, BHT, cancer, coronary thrombosis, cysteine, Dr. Wilfred E. Shute, ethoxyquin, free radicals, genetic mutations, glutathione, heart attack, L-Dopa, Lasker research award, peroxidized fats, PGI, phenolic amino acid, platelet, prostacyclin, prostacyclin synthetase, selenium, stroke, sulfur, thromboxane, tyrosine, vitamin A, vitamin c, vitamin E
Skin is a visible organ which suffers cross-linking damage. However, unlike other tissues, skin is exposed to considerable ultraviolet light (UV) energy from sunlight. Ultraviolet light is a major cause of skin cross-linking. This type of damage can be prevented or retarded by staying out of sunlight or using sun-block preparations containing esters of PABA […]
Read more Cross-linked Molecules and Aging in Skin, Arteries, and Other Tissues IV
- beta carotene, body clock, canthaxanthin, carotenoid, Cross-linking, death clock, DNA, Dr. W. Donner Denckla, nucleic acid, Orobronze, PABA, pituitary gland, RNA, skin, ultraviolet light, UV damage, UV light, vitamin A, vitamin b
As we mentioned earlier, some nutrients effective to a degree in slowing cross-linking include cysteine (a sulfur-containing amino acid, which helps maintain sulfur in proteins in the reduced state); vitamins A, B-1, B-5, B-6, C, E; the mineral selenium; and other antioxidants. Removal of calcium and heavy metals from collagen by chelating agents may be […]
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- amino acid, bromelain, chelating agent, collagen, Cross-linking, cysteine, Dr. Johan Bjorksten, micro-protease, nutrients, papain, papaya, pineapple, proteolytic enzymes, sulfur, vitamin A, vitamin B1, vitamin B5, vitamin B6, vitamin c, vitamin E
Proteins are complex molecules, made up of amino acids, which perform a wide variety of functions in the human body, from chemical reaction-controlling enzymes, to structural molecules like collagen, to necessary components in human memory. In order to function properly, proteins must assume a correct three-dimensional configuration. In their proper shape, some proteins act as […]
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- acetaldehyde, alcohol, amino acid, arteries, blood vessels, chelating agent, collagen, connective tissue, Cross-linking, diabetes, EDTA, EGTA, enzymes, free radicals, hemorrhage, ketones, lipids, metal ions, molecules, muscles, nitrogen, oxidation, oxygen, plasma, plasma lipids, protein, proteins, smog, sodium citrate, sulfur, tobacco, unsaturated fats, vitamin c, wine
As you grow older, your body becomes stiffer, less elastic, and less agile. This is due to cross-linking at a molecular level. You become stiffer for the same reason that old rubber becomes brittle and stiff—your large structural molecules such as collagen (an important protein in connective tissues) are welded together by cross-links. This process […]
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- agile, bitamin B1, collagen, Cross-linking, flexibility, molecules, nutrients, PABA, vitamin A, vitamin B5, vitamin B6, vitamin c, vitamin E
Empiricism may serve to accumulate facts, but it will never build science. The experimenter who does not know what he is looking for will not understand what he finds. —Claude Bernard, 1813-1878 When your skin wrinkles, or arteries or bread hardens, or rubber becomes brittle, or old Jell-O® stiffens, we are seeing examples of the […]
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- acetaldehyde, alcohol, amino acid, arteries, atherosclerosis, cancer, cells, Cross-linking, cysteine, DNA, eggs, esters, flexibility, hemorrhage, liver, metabolism, molecules, nutrients, PABA, proteins, rats, RNA, sunlight, tissues, tobacco, ultraviolet light, vitamin b, vitamin B1, vitamin c, wrinkles