interfere with PAH activation and/or binding to DNA, thereby reducing the amount of DNA damage done. Rate and accuracy of repair of ultraviolet (UV) light damage to DNA in seven mammalian species’ cultured fibroblasts correlates with maximum species life span. Repair of damage to DNA plays a vital role in retarding aging, although the importance […]
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- acetaldehyde, air pollution, cancer, DNA, Dr. R. B. Setlow, Dr. Ronald W. Hart, enzyme, fibroblasts, free radicals, genetic disease, globulin, glutathione peroxidase, hemoglobin, life span, nitrogen oxide, ozone, PAH, peroxyacetylnitrile, progeria, skin erythema, SOD, superoxide dismutase, ultraviolet light, UV, Xeroderma pigmentosa
… Spontaneous mutations, cancer, and aging can be looked upon as a result of continuous “internal radiation” while these same processes produced by external radiation are largely the result of an increment in the amount of total “radiation” to which the organism is exposed. —Dr. Denham Harman, originator of the free radical theory of aging […]
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- atherosclerosis, cancer, DNA, enzymes, fats, free radicals, glutathione peroxidase, hydrogen peroxide, immune system, molecules, mutations, nucleic acid, oxidation, radiation, RNA, SOD, superoxide dismutase, vitamin c, vitamin E
PIC HERE Because of the toxicity of high concentrations of oxygen (via free radical mechanisms), hyperbaric oxygen (higher than normal atmospheric pressure) should be used with great caution. In very short repeated exposures it is possible that free radical destroying enzymes, such as SOD, may be induced to higher levels, thus increasing the patient’s overall […]
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BHT has extended the life spans of mice in experiments by Dr. Denham Harman. In some species which have a naturally short life span and tend to die of cancer, the BHT’s life extending effects probably stemmed from its suppression of cancer development. Harman has also demonstrated an increase in average life span with BHT […]
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- antioxidants, autoxidation, beta-blocker drug, BHA, BHT, brain, calories, cancer, cardiovacular disease, central nervous system, cerebral-spinal fluid, CNS, copper, CSF, cysteine, docosahexanoic acid, Dr. Denham Harman, free radical theory of aging, free radicals, free-radicals, high blood pressure, immune system, linolenic acid, lipids, low dose of aspirin, oxidation, polyunsaturated fats, propranolol, safflower oil, saturated fats, selenium, SOD, spinal cord, stomach cancer, vitamin A, vitamin B1, vitamin B5, vitamin B6, vitamin c, vitamin E, zinc
Free radicals are intermediates in many normal and necessary metabolic reactions. Thus, all oxygen-using organisms have had to evolve defensive mechanisms against free radicals: The enzymes catalase and peroxidase break down hydrogen peroxide and other peroxides, superoxide dismutase (called SOD) controls the superoxide free radical, and glutathione peroxidase also controls peroxides. Antioxidants such as vitamins […]
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- acid hydrolases, air pollution, antioxidants, bacteria, bioavailability, brain, cancer, catalase, Cross-linking, enzymes, free radicals, genetic defects, glutathione peroxidase, heart, hyaluronate, hydrogen peroxide, liver, lysosomes, malonaldehyde, maximum lifespan potential, metabolic reactions, mlp, mutagen, oxidation, peroxidase, peroxidized fats, progeria, radiodurans, red blood cells, rheumatoid arthritis, selenium, SOD, superoxide dimutase, superoxide dismutase, superoxide radicals, vitamin E