A very dramatic story about the effects of L-Dopa on twenty patients with severe Parkinson’s disease is contained in Oliver W. Sack’s book Awakenings. Between 1916 and 1927, nearly five million people fell victim to encephalitis lethargica (sleeping sickness). A third of those affected died either in a coma or in a profound state of […]
Read more The Decline of Your Brain’s Chemical Messengers V
- antioxidants, autoxidation, blood-brain barrier, choline, Deaner, dopaminergic nerve cell receptors, Dr. George C. Cotzias, encephalitis lethargica, free radicals, growth hormone, hydergine, hydrogen peroxide, L-Dopa, lecithin, Parkinsonism, phenothiazines, pituitary gland, selenium, tardive dyskinesia, vitamin B1, vitamin B5, vitamin B6, vitamin c, vitamin E, zinc
Deaner® is a prescription drug which is available in the United States. We have observed 300 milligrams per day of Deaner® remove all visible lipofuscin age pigment (liver spots) from the skin of a man in his mid-60s. After a few months, his age spots had faded appreciably and were completely gone in about two […]
Read more Accumulated Wastes: Those Telltale Brown Spots III
Although the work was directed at amyloid formation, data was also cited that showed the pronounced beneficial effect on the mice’s mortality rate by adding Santoquin antioxidant to the diet. Without the antioxidant in the diet, 20% survived to 1814 months; on diets with 0.2% Santoquin, 20% survived for 23 months. This was not the […]
Read more Our Subversive Free Radicals VIII
- amino acid, amyloid formation, antioxidants, encephalomalacia, free radicals, lipids, Monsanto, nutrients, oxidation, oxygen, peroxides, Santoquin, unsaturated fats, unsaturated oils, vitamin E, vitamins
Santoquin antioxidant, more familar as a commonly-used feed ingredient by its generic nickname of ethoxyquin, is feed- grade: 6-ethoxy-1,2-dihydro-2,2,4-trimethylquinoline. The structural formula looks like this: H NW CH, CH, CH;CH,O a CH; One of the most familiar (and perhaps important) antioxidants that Mother Nature provides living bodies is Vitamin E. Its most potent isomer, -tocopherol […]
Read more Our Subversive Free Radicals VII
- aging, aging pigments, amyloid plaques, amyloidosis, antioxidants, Cross-linking, digestion, Dr. B. L. Strehler, Dr. Denham Harman, Dr. Johan Bjorksten, Dr. William A. Pryor, ethoxyquin, free radicals, metabolism, Monsanto, peroxides, Santoquin, senile plaques, vitamin E
Hydergine® (made by Sandoz), a prescription drug, can prevent a considerable amount of the damage caused by free radicals in the brain. It is a very powerful antioxidant. It is useful in older persons who have a degree of cerebral hypoxia (insufficient oxygen), in preventing birth defects resulting from inadequate oxygen to the fetal brain […]
Read more Our Subversive Free Radicals VI
- 2-MEA, age pigments, alertness, amino acid, antioxidants, B-cells, BHT, birth defects, brain, brain damage, cerebral palsy, cognitive functions, cysteine, ethoxyquin, extending life span, free radicals, hydergine, hypoxia, increased intelligence, Lipofuscin aging pigment, Monsanto, neurons, nootropic, peroxidized fats, prescription drugs, proteinaceous material, sandoz, Santoquin, selenium, skin, sodium hypophosphite, T-cells, vitamin A, vitamin E, zinc
BHT has extended the life spans of mice in experiments by Dr. Denham Harman. In some species which have a naturally short life span and tend to die of cancer, the BHT’s life extending effects probably stemmed from its suppression of cancer development. Harman has also demonstrated an increase in average life span with BHT […]
Read more Our Subversive Free Radicals V
- antioxidants, autoxidation, beta-blocker drug, BHA, BHT, brain, calories, cancer, cardiovacular disease, central nervous system, cerebral-spinal fluid, CNS, copper, CSF, cysteine, docosahexanoic acid, Dr. Denham Harman, free radical theory of aging, free radicals, free-radicals, high blood pressure, immune system, linolenic acid, lipids, low dose of aspirin, oxidation, polyunsaturated fats, propranolol, safflower oil, saturated fats, selenium, SOD, spinal cord, stomach cancer, vitamin A, vitamin B1, vitamin B5, vitamin B6, vitamin c, vitamin E, zinc
Mutations to your DNA caused by free radicals are a major cause of cancer. Free radicals can make blood clot abnormally in our arteries by destroying our body’s ability to make PGI, (prostacyclin), a natural anti-clot hormone found in healthy arteries. Free radicals are also implicated in arthritis. Most of the brain damage caused by […]
Read more Our Subversive Free Radicals II
- age pigment accumulation, amino acid, antioxidants, arthritis, bacteria, BHA, BHT, bioflavinoids, blood clot, blood clots, cancer, catecholic amino acid, ceroid, collagen, Cross-linking, cysteine, DNA, elastin, enzymes, free radicals, glutathione, grapes, hemorrhage, hydrogen peroxide, Hydroxyl radicals, L-Dopa, lipid membrane peroxidation, lipids, lipofuscin, lysosomal membranes, mutations, oxidative polymerization, oxygen, peroxidation, peroxidized lipids, PGI, phenolic amino acid, prostacyclin, proteins, radiation, rancid fats, RNA, selenium, sodium hydrogen urate, superoxide radicals, triamino acid, tyrosine, unsaturated fats, uric acid, viruses, vitamin A, vitamin B1, vitamin B5, vitamin B6, vitamin E, xanthine oxidase, zinc
Free radicals are intermediates in many normal and necessary metabolic reactions. Thus, all oxygen-using organisms have had to evolve defensive mechanisms against free radicals: The enzymes catalase and peroxidase break down hydrogen peroxide and other peroxides, superoxide dismutase (called SOD) controls the superoxide free radical, and glutathione peroxidase also controls peroxides. Antioxidants such as vitamins […]
Read more Our Subversive Free Radicals III
- acid hydrolases, air pollution, antioxidants, bacteria, bioavailability, brain, cancer, catalase, Cross-linking, enzymes, free radicals, genetic defects, glutathione peroxidase, heart, hyaluronate, hydrogen peroxide, liver, lysosomes, malonaldehyde, maximum lifespan potential, metabolic reactions, mlp, mutagen, oxidation, peroxidase, peroxidized fats, progeria, radiodurans, red blood cells, rheumatoid arthritis, selenium, SOD, superoxide dimutase, superoxide dismutase, superoxide radicals, vitamin E
where: R is an organic molecule ROOH is an organic peroxide R:R are two organic molecules which have been cross-linked to- gether Oz is oxygen Cu is copper, Fe is iron *is the unpaired electron H is a hydrogen atom HO* is a superoxide free radical RO,* and R* are organic free radicals Note that […]
Read more Our Subversive Free Radicals IV
- aging, amino acid, antioxidants, artery walls, atherosclerotic plaque cells, BHA, BHT, cancer, coronary thrombosis, cysteine, Dr. Wilfred E. Shute, ethoxyquin, free radicals, genetic mutations, glutathione, heart attack, L-Dopa, Lasker research award, peroxidized fats, PGI, phenolic amino acid, platelet, prostacyclin, prostacyclin synthetase, selenium, stroke, sulfur, thromboxane, tyrosine, vitamin A, vitamin c, vitamin E
Proteins are complex molecules, made up of amino acids, which perform a wide variety of functions in the human body, from chemical reaction-controlling enzymes, to structural molecules like collagen, to necessary components in human memory. In order to function properly, proteins must assume a correct three-dimensional configuration. In their proper shape, some proteins act as […]
Read more Cross-linked Molecules and Aging in Skin, Arteries, and Other Tissues III
- acetaldehyde, alcohol, amino acid, arteries, blood vessels, chelating agent, collagen, connective tissue, Cross-linking, diabetes, EDTA, EGTA, enzymes, free radicals, hemorrhage, ketones, lipids, metal ions, molecules, muscles, nitrogen, oxidation, oxygen, plasma, plasma lipids, protein, proteins, smog, sodium citrate, sulfur, tobacco, unsaturated fats, vitamin c, wine