There are several nutrients and prescription drugs which cause GH release. These include the amino acids arginine and ornithine and the prescription drugs L-Dopa (another amino acid), bromocriptine (Parlodel®, by Sandoz), and vasopressin (Diapid®, Sandoz nasal spray). In one study, 1/2 gram per day of L-Dopa increased the growth hormone output of men in their 60s (who were not suffering from Parkinson’s disease)back up to near young adult levels. This may be a partial solution to the problem of cessation of exercise-stimulatéd growth hormone release in persons over the age of about 30.
GROWTH HORMONE CAUTION: Inappropriate use of GH releasers may have adverse consequences. They should not be used by persons who have not completed their long-bone growth (that is, who have not grown to their full height) unless they have been advised to do so by their physician.
After full height is attained, GH will not cause further height increases. Excess GH will cause the skin to grow so rapidly that it becomes noticeably coarser and thicker; this effect is reversible when excess GH is withdrawn. Very excessive GH over an extended period of time can cause irreversible enlargement of joint diameter (which may be unsightly but is
usually not dangerous) and lowering of voice pitch due to larynx growth.
The maintenance of extremely high levels of growth hormone (above normal teenage to young adult levels) for extended periods of time requires further safety research. In some GH releaser experiments on animals either
previously or subsequently given cancer, the GH releasers usually caused an improvement. At Cornell University Medical Center, however, hypophysectomy (surgical removal of the hypothalamus) in. women with advanced metastatic breast cancer has sometimes produced dramatic improvements.
Since this procedure affects many other hormones besides GH, including LHRH, LH, FSH, TRF, TSH, thyroid, prolactin, estrogens, progestins, endorphins, beta lipotropin, etc., it is not yet clear what is going on here.
In recent research, it was found that L-Dopa given to old rats could restore their swimming abilities to that of young adult rats. The old rats, before getting L-Dopa, swam in a more vertical position and used the energy they did have in a very inefficient manner, sinking under the water after a relatively short time. The old rats, after getting L-Dopa, swam in a more horizontal position (like the young rats) and were indistinguishable from the young rats in their swimming performances. L-Dopa is used in the brain to make dopamine and norepinephrine. Dopamine is a major neurotransmitter involved in motor (muscular movement) control. Parkinsonism patients, who have lost their fine motor control and developed tremors, are often benefited by L-Dopa or other dopaminergic stimulants. (In many cases, a combination of bromocriptine [Parlodel®, Sandoz plus a somewhat reduced dosage of L-Dopa provides better control of Parkinsonism with fewer side effects.) L-Dopa, like other catechols, is a
good antioxidant and has been used for radiation protection.
CAUTION: Long use at high dose levels; especially without
adequate intake of other antioxidants, can.lead to undesirable
autoxidation side effects. .
Proteolytic enzymes—enzymes that dissolve proteins— increase the turnover rate for proteins by stimulating protein manufacture and repair. Examples of common proteolytic enzymes are bromelain (in raw pineapple) and papain (in raw papaya). Cooked or canned pineapple and papaya do not contain these enzymes, which are destroyed by heating. These enzymes can slowly dissolve away damaged protein tissues, speeding up healing and repair. They have been used to reduce inflammation and edema and to treat many athletic injuries. If you eat raw pineapple or papaya for these enzymes, watch out for the development of sore and tender corners of your lips (they are tenderized in the same way that proteolytic enzymes tenderize meat). When this occurs, stop eating these fruits. Promptly washing your mouth after eating raw pineapple or papaya is a good idea, if you eat them frequently.
CAUTION: Do not eat raw pineapple or papaya if you have an ulcer. Athletes frequently take tablets of Ananase® (Rorer), a prescription form of bromelain, for athletic injuries.
It has been observed that women athletes sometimes stop menstruating. Recently, Harvard researchers suggested a possible reason. They noted that girls at the start of menstruation need to have-a body fat content of about 17 percent or menstruation will not begin. When nonathletic women lose 10 to 15 percent of their body weight, including about a third of their body fat, they usually stop menstruating. The researchers suggest that this may be an adaptation to prevent skinny women from becoming pregnant, because until recently an adequate body store of fat was necessary to survive food shortages, which were frequent.
Athletic injuries are common. DMSO (dimethy] sulfoxide) is very helpful in reducing damage in many injuries. In crushing injuries, including bruises, blood leaks into the damaged tissues. When the red blood cells hemolyze (break down), they release copper and iron, which stimulate the production
in these injured tissues of free radicals.
DMSO is an especially effective scavenger of a particular type of free radical, the hydroxyl radical. When DMSO (a clear liquid) is placed on the
skin over the injury, it actually moves through the skin and into the deeper tissues, where it inhibits destruction by free radicals, allowing healing to proceed more rapidly. DMSO has been used successfully in some cases of spinal cord injury where, if a solution in physiological saline is injected soon enough (within a few hours after the injury), it has helped prevent the development of paralysis. DMSO is available as a prescription drug and is also sold in some health food stores.
Be careful that you buy a high-purity grade of DMSO
Biochemistry has a great deal more to offer the athlete, whether amateur or professional. It is actually possible to remodel your body, adding muscles and eliminating fat, with far less effort than with conventional means. The aging effects that eventually end all athletic careers can be delayed for at
least several years, and perhaps for decades.
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