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Because of the toxicity of high concentrations of oxygen (via free radical mechanisms), hyperbaric oxygen (higher than normal atmospheric pressure) should be used with great caution. In very short repeated exposures it is possible that free radical destroying enzymes, such as SOD, may be induced to higher levels, thus increasing the patient’s overall ability to handle free radicals. However, excessively long exposures would cause damage by creating conditions for massive peroxidations, especially in patients with a low level of antioxidants in their bodies. Both too high and too low levels of oxygen lead to increased radical activity. As Dr. Harry Demopoulos and others have shown, oxygen gas (O2) can quench free radicals. He has found that the principal destructive consequence of hypoxia (oxygen deficiency) in tissues is due to free radicals produced under the hypoxic condition. When the amount of oxygen drops below about half of normal, the free radical generating ability of oxygen reacting with fats is almost as great as at full oxygen supply, but the free radical
inhibiting activity of oxygen is mostly lost. This is why brain damage normally occurs within minutes after stoppage of breathing or brain blood circulation. Hydergine® can extend this safe period very substantially.
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